Contract research - Good Animal Practice (GAP) Certified

CNBE's experienced staff can work with you to design and execute cost-effective protocols for your exploratory or screening studies

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Services

  • EXPLORATORY TOXICITY
    • Dose-range finding
    • MTD, NOEL, NOAEL
    • Acute and chronic toxicity
    • Toxicity in hyperlipidemic rats
    • Immunotoxicity
    • Skin reaction/Draize scoring/biopsies
    • Delayed-type hypersensitivity (DTH)
    • Blood chemistry/hematology/histopathology
  • PHARMACOKINETIC
    • Multiple routes of administration (per os, IV, IP, SC, IM, ID, IT and Ive)
    • Multiple animal species (including non-human primate)
    • Sampling & microsampling (sang, sera, plasma, urine, organs)

PROOF-OF-CONCEPT STUDIES (DRUG EFFICACY)

 

  • Infectious diseases (BSL-2; bacteria, virus, toxin, etc. )
  • Infectious diseases (BSL-3; bacteria, virus, toxin, etc.)
  • Allergy (skin infiltration)
  • Dermatology
  • Stem cell safety
  • Inflammation
  • Arthritis
  • Autoimmune diseases
  • Vaccine
  • Polyclonal antibody production
  • Nutrition evaluation
  • Acute liver injury
  • Wound healing

 

ONCOLOGIE (NEW ALLIANCE):

 

  • Partnership in oncology with Woodland Biosciences USA (www.woodlandbiosciences.com)
  • In vitro screening services using 2D and 3D cultures and identification of mechanism of action
  • DMPK in tumor bearing animals
  • Chemotherapy-related hematological toxicity
  • Syngeneic animal cancer models and xenograft studies (260 cell lines in 19 indications)
  

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